Over 1 million couples seek fertility care each year in the U.S. Within this group 200,000+ IVF cycles are performed annually.

If you are considering IVF, there is no shortage of testing and information you can go through on the female side. What’s missing is a solid grasp of the male’s role in IVF success. Even after fertilization, an embryo can fail to develop because of genetic problems on the male side.

“Failure to implant, poor embryo development, and even miscarriage, could all be the result of male factors.”

If a couple goes to see a fertility specialist, the male partner(s) will do a semen analysis. The semen analysis is the standard first tool for checking male fertility. This test is looking at sperm count, motility (movement), and morphology (shape).

It’s a valuable tool, but when it’s the only test done on a man it promotes an outdated view of the male role in conception. The semen analysis only focuses on sperm production to fertilization.

If a sperm can fertilize an egg, the male’s role is finished, right? Any problems from then on are happening in the female’s body, so the problem must be hers.

To understand just how wrong this is, you need to understand how an embryo forms.

First, sperm and egg cells combine into a single cell with half the DNA of each parent. The information provided in the DNA is used to guide the fertilized egg as it divides, over and over, forming a highly-developed fetus.

Male Factor Infertility The Seed Test by Episona

The male still has an active role in embryo development through his DNA. Abnormalities in his sperm DNA could be complicating or causing fertility problems at every stage of embryonic development. Failure to implant, poor embryo development, and even miscarriage, could all be impacted by male factors which are missed by the semen analysis.

Without understanding that a problem may be originating on the male side, couples can sink a fortune into the wrong treatment approach, as well as have unrealistic expectations about the chances of success.

Example:

A couple has unexplained infertility, but a semen analysis shows the man’s sperm looks normal, so they rule him out. They try IUI three times. Fail. Fail. Fail. They are committed and move on to IVF. IVF fails. IVF with ICSI fails. At this point they might move on to an egg donor or even a surrogate. It still fails. At this point they stop trying and are left without answers or a child.

Some version of this happens in more cases than you might think and the problem may have been on the male side all along, undetected by a semen analysis.

Sperm DNA Testing

A new sperm DNA test, Seed, is the first of its kind. Seed looks at 480,000 regions on sperm DNA to find abnormalities which cannot be identified with a semen analysis. These abnormalities are used to create a personal profile of a man’s risk for poor sperm function and poor embryo development. It also highlights any abnormalities in genes with a known role in fertility.

The Seed Fertility Test from Episona
The Seed Fertility Test from Episona

For example, the gene CATSPER1 is well documented and essential for sperm to enter the egg during fertilization.

Another gene, MIR223 is believed to be important for embryo implantation. While the ID3 gene is crucial for proper embryo development.

Seeing abnormalities in specific genes can help a doctor understand where problems may occur.

To get a complete picture of male fertility, you need to look beyond semen parameters. Seed discovers problems at the level of DNA that affect sperm function, helping you understand your risk for an unsuccessful cycle and identifying factors that may affect success.

Fertility treatment is an expensive and emotionally difficult process. Don’t make it harder by acting without enough information. If you are considering IVF or have been diagnosed with unexplained infertility, talk to your fertility specialist about Seed.

Learn More About the Seed Test

About the Author:

Alan Horsager is Co-Founder and CEO of Episona, a reproductive health company which offers a new sperm DNA test, Seed. You can visit Episona.com to learn more.

44 COMMENTS

  1. This is really interesting, You are a very skilled blogger.
    I have joined your feed and look forward to seeking more of your great post.

    Also, I have shared your website in my social networks!

  2. I am not sure where you’re getting your information, but
    great topic. I needs to spend some time learning more or understanding
    more. Thanks for great information I was looking for this info for
    my mission.

  3. Hello, i think that i saw you visited my web site so i came to “return the favor”.I am attempting to find things to
    improve my site!I suppose its ok to use some of your ideas!!

  4. Hello, I believe your blog could possibly be having browser compatibility issues.
    When I look at your blog in Safari, it looks fine however when opening in IE,
    it’s got some overlapping issues. I just wanted to give you a quick heads up!
    Besides that, excellent site!

  5. Hey just wanted to give you a brief heads up and let you know a few of
    the pictures aren’t loading correctly. I’m not sure why but I think
    its a linking issue. I’ve tried it in two different internet browsers and both show
    the same outcome.

  6. Hi, Neat post. There is an issue together with your website in internet explorer, might test this?
    IE nonetheless is the marketplace chief and a big component of
    folks will pass over your fantastic writing
    because of this problem.

  7. I was recommended this blog by my cousin. I am not sure whether this post is written by him as no one else know
    such detailed about my problem. You are incredible!
    Thanks!

  8. It’s appropriate time to make some plans for the future and it is
    time to be happy. I have read this post and if I could I wish to suggest
    you some interesting things or advice. Maybe
    you can write next articles referring to this article.
    I wish to read even more things about it!

  9. You’re so cool! I don’t believe I’ve truly read through
    a single thing like this before. So wonderful to find another person with
    a few genuine thoughts on this issue. Seriously..
    thank you for starting this up. This website is one thing that’s needed on the
    web, someone with some originality!

  10. You really make it seem so easy with your presentation but I find this topic
    to be really something that I think I would never understand.

    It seems too complex and extremely broad for me.

    I’m looking forward for your next post, I’ll try to get the
    hang of it!

  11. Does your site have a contact page? I’m having trouble locating it
    but, I’d like to shoot you an e-mail. I’ve got some recommendations for your blog you
    might be interested in hearing. Either way, great website
    and I look forward to seeing it develop over time. pof natalielise

  12. After looking into a few of the blog posts on your site, I
    seriously appreciate your way of writing a blog.
    I bookmarked it to my bookmark website list and will be checking back soon. Please check out my website too
    and let me know your opinion.

  13. Hey just wanted to give you a quick heads up and
    let you know a few of the images aren’t loading properly.
    I’m not sure why but I think its a linking issue.

    I’ve tried it in two different web browsers and both show the same
    outcome.

  14. I loved as much as you’ll receive carried out right here.
    The sketch is attractive, your authored subject matter stylish.
    nonetheless, you command get bought an edginess over that you wish be delivering the following.
    unwell unquestionably come further formerly again as
    exactly the same nearly very often inside case you shield
    this hike.

  15. I have been surfing online greater than 3 hours nowadays, but I never found any interesting article like yours.
    It’s lovely worth sufficient for me. In my view, if all website
    owners and bloggers made just right content material as you
    probably did, the web might be much more useful
    than ever before.

  16. I’ve been browsing online more than three hours today, yet I never found any interesting article
    like yours. It is pretty worth enough for me. In my opinion, if all webmasters and bloggers made good content as
    you did, the web will be a lot more useful than ever before.

  17. Howdy! This article could not be written much better! Going through this article reminds me of my previous roommate! He always kept talking about this. I will send this information to him. Pretty sure he’ll have a great read. I appreciate you for sharing!

LEAVE A REPLY

Please enter your comment!
Please enter your name here