Over 1 million couples seek fertility care each year in the U.S. Within this group 200,000+ IVF cycles are performed annually.

If you are considering IVF, there is no shortage of testing and information you can go through on the female side. What’s missing is a solid grasp of the male’s role in IVF success. Even after fertilization, an embryo can fail to develop because of genetic problems on the male side.

“Failure to implant, poor embryo development, and even miscarriage, could all be the result of male factors.”

If a couple goes to see a fertility specialist, the male partner(s) will do a semen analysis. The semen analysis is the standard first tool for checking male fertility. This test is looking at sperm count, motility (movement), and morphology (shape).

It’s a valuable tool, but when it’s the only test done on a man it promotes an outdated view of the male role in conception. The semen analysis only focuses on sperm production to fertilization.

If a sperm can fertilize an egg, the male’s role is finished, right? Any problems from then on are happening in the female’s body, so the problem must be hers.

To understand just how wrong this is, you need to understand how an embryo forms.

First, sperm and egg cells combine into a single cell with half the DNA of each parent. The information provided in the DNA is used to guide the fertilized egg as it divides, over and over, forming a highly-developed fetus.

Male Factor Infertility The Seed Test by Episona

The male still has an active role in embryo development through his DNA. Abnormalities in his sperm DNA could be complicating or causing fertility problems at every stage of embryonic development. Failure to implant, poor embryo development, and even miscarriage, could all be impacted by male factors which are missed by the semen analysis.

Without understanding that a problem may be originating on the male side, couples can sink a fortune into the wrong treatment approach, as well as have unrealistic expectations about the chances of success.

Example:

A couple has unexplained infertility, but a semen analysis shows the man’s sperm looks normal, so they rule him out. They try IUI three times. Fail. Fail. Fail. They are committed and move on to IVF. IVF fails. IVF with ICSI fails. At this point they might move on to an egg donor or even a surrogate. It still fails. At this point they stop trying and are left without answers or a child.

Some version of this happens in more cases than you might think and the problem may have been on the male side all along, undetected by a semen analysis.

Sperm DNA Testing

A new sperm DNA test, Seed, is the first of its kind. Seed looks at 480,000 regions on sperm DNA to find abnormalities which cannot be identified with a semen analysis. These abnormalities are used to create a personal profile of a man’s risk for poor sperm function and poor embryo development. It also highlights any abnormalities in genes with a known role in fertility.

The Seed Fertility Test from Episona
The Seed Fertility Test from Episona

For example, the gene CATSPER1 is well documented and essential for sperm to enter the egg during fertilization.

Another gene, MIR223 is believed to be important for embryo implantation. While the ID3 gene is crucial for proper embryo development.

Seeing abnormalities in specific genes can help a doctor understand where problems may occur.

To get a complete picture of male fertility, you need to look beyond semen parameters. Seed discovers problems at the level of DNA that affect sperm function, helping you understand your risk for an unsuccessful cycle and identifying factors that may affect success.

Fertility treatment is an expensive and emotionally difficult process. Don’t make it harder by acting without enough information. If you are considering IVF or have been diagnosed with unexplained infertility, talk to your fertility specialist about Seed.

Learn More About the Seed Test

About the Author:

Alan Horsager is Co-Founder and CEO of Episona, a reproductive health company which offers a new sperm DNA test, Seed. You can visit Episona.com to learn more.

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  94. Talleres mediavilla es una empresa familiar nacida en 1912 al frente de la que se encuentra la cuarta generación. Cuando alguien ajeno a nuestro sector, entra por primera vez en un taller de mecanizado, una de las primeras preguntas que realiza es acerca de ese líquido” que fluye dentro de las máquinas durante el proceso de arranque de viruta.

  95. Los brutos de los que suelen obtenerse este tipo de pieza de gran esbeltez presentan un estado de tensiones residuales provenientes de las fases de procesado (extrusión, tratamiento térmico, …) previas al mecanizado 5. Al eliminar los volúmenes de material necesarios para la obtención de la pieza final, la necesidad de alcanzar un nuevo equilibrio de fuerzas en la pieza mecanizada hace que ésta se deforme tras la liberación de las fuerzas de amarre, obteniéndose una geometría final diferente a la mecanizada inicialmente 3,4.

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  143. Reparación de electrodomésticos, calderas de gas, calentadores y termos eléctricos de todas las marcas. Es entre las mayores multinacionales que opera en los mercados de generación, comercialización y distribución de energía eléctrica y cuenta con seiscientos setenta clientes del servicio en España. Costo rebajado veintidos por ciento hasta el día quince en todo género de reparaciones y también instalaciones.

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  146. Cuando el sujeto pasivo elabore individual y aisladamente el vino con uva de su propia cosecha, la cuota será el 25 de la señalada en este epígrafe. Nota: Este epígrafe comprende la preparación (gasificación, etc.) y envasado de aguas minerales naturales en las fuentes manantiales. Se incluye en este epígrafe la fabricación de productos en polvo, jarabes y concentrados y bases para la fabricación de estas bebidas. Epígrafe 429.2.- Primera transformación del tabaco sin elaboración de cigarros, cigarrillos, picadura, etc.

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  151. Las marcas y logos de cada servicio técnico expuestos en este sitio web son propiedad de sus titulares y están protegidos por las leyes del copyright. Servicio Técnico Multi-Marca de Reparaciones e Instalaciones de calderas de Gasoil en la sierra norte de Madrid. Reparacion de Calderas, termos, calentadores y todo tipo de sistemas de calefaccion por tecnicos calderistas en Madrid. Reparacion de Calderas Majadahonda Madrid es una empresa de instaladores de calderas en Majadahonda.

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  156. BOSCH surte al ramo de los electrodomésticos de gama blanca de una línea de alta gama de neveras, congeladores y vinotecas de las más extensas del mercado. En este caso, un dispositivo de inyección de aire frío asegura la recuperación del frío de forma automática y ultrarrápida para evitar cortes en la cadena del frío. Se pueden encontrar frigoríficos americanos con dispensador de hielo y autonomía por corte de energía de hasta 5 horas.

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  158. Nuestros técnicos trabajan todo tipo de electrodomésticos de la gama blanca, consúltenos si su lavavajillas Siemens no seca bien si la lavadora Siemens no saca agua bien cualquier problema con la secadora Siemens cuando no seca bien cuando un frigorífico Siemens no enfría. Además y como ATEM siempre piensa en sus clientes, queremos ofrecerles DESPLAZAMIENTO GRATIS del técnico a su casa.

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  161. En la entrada de aire podemos fabricarnos un pequeño filtro para evitar que entren porquerías al motor, con un trozo de esponja y una brida sobre un trozo de tubo. Si hacemos vacío también podría ser interesante poner un vacuómetro en la entrada de aire (con su correspondiente T), dependiendo del tipo de trabajos que realicemos. Controlo la presion en el cilindro con un presostato de baja y un relevo, lo tengo saliendo en 100 psi y repone en 70 psi, la unidad se calinta mucho.

  162. Entre los problemas comunes que nos hemos encontrado en Parla podemos garantizar la solución inmediata de los siguientes: Apagones, sobrecarga de la red, reparación de enchufes e interruptores, existe un enchufe sin corriente, salta el interruptor diferencial, la tarifa nocturna no carga, salta frecuentemente el limitador de potencia, diferenciales y cualquier derivación, parte de la vivienda local sin luz.

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  166. Somos una empresa taiwanesa con más de 20 años de experiencia en la producción de piezas de decoletaje de precisión. En constante crecimiento, cuenta con una experiencia y una seriedad en el sector del decoletaje suficientemente contrastada. Si se necesitan otros tipos de instrumentos fabricados mediante decoletaje industrial para otros ámbitos, en Talleres Floper también podemos hacerlo por ti.

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  168. Nuestro valor añadido y agilidad de respuesta están basados en la integración de los procesos productivos, desde el corte de la materia prima, hasta el acabado, ya sea recubrimiento electrolítico, desengrasado, pasivado pintura. With aluminium cylinder heads, a key engine part, it has recently become common to supply the parts to the final customers pre-machined.

  169. Como es muy fácil aprender a manejarlos -aunque no se tengan conocimientos de código G-, son unas máquinas perfectas para talleres que empiezan como puerta de entrada al mecanizado CNC. Eje Y: La capacidad de tornear y fresar piezas complejas y de realizar varias operaciones en una sola máquina incrementa la productividad, reduce el tiempo de manipulación por parte del operario y mejora la precisión de las piezas.

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