What if you not only had a condition that made you miserable, but was also so embarrassing you might even avoid discussing it with your doctor for two years? This fall we have been shining a light on chronic idiopathic constipation (CIC) to help the approximately 1 in 7 adults in the United States suffering from the condition, and also to highlight a treatment option for adults with CIC.1

Constipation is something that most people have experienced at one time or another. But, for some, long periods of constipation without a known cause could be CIC.CIC is one of the most common functional gastrointestinal disorders worldwide, affecting approximately 33 million Americans.1,2

Although it is common, CIC poses a significant treatment challenge, as the condition is chronic in nature and can cause a wide range of symptoms.1,2 Lots of folks start out trying to tackle the problem themselves with lifestyle changes and products available over-the-counter such as stool softeners and laxatives.2 When people can’t find relief from their constipation, they can get stuck in a cycle of discomfort, both from their constipation and diarrhea.

A Mother and her son is having fun at the beachThe activities that I enjoy most in life are taking trips both near and far, spending long days at the beach, and going to plays and concerts. As I’ve learned more about CIC, I better understand the struggles people face with how they manage it, and how it impacts their daily lives. I’ve often wondered how many of those activities I’d be able to do if I were going through the same thing. If I was stressed about where I might find a bathroom or how long I would need to be in there, would I even consider a day out of the house? CIC patients shouldn’t have to forgo certain activities just because of their condition. Adults with CIC should work closely with their physician to determine an appropriate option that can address symptoms while minimizing treatment-related adverse events, such as nausea and diarrhea.

When managing constipation, you shouldn’t have to make compromises. Trulance is an available treatment option indicated for adults living with CIC.3 Trulance is designed to act just like uroguanylin by working primarily in the small intestine to help regulate the amount of fluid needed for normal bowel function.3 Diarrhea is the most common side effect and can sometimes be severe.3 It is important to discuss the potential benefits and side effects with your doctor.3 Are you ready to talk to your doctor about Trulance? See additional important safety information below.

To learn more and help prepare for a discussion about treating your CIC with Trulance, create your own customized Doctor Discussion Guide. Visit www.TRULANCE.com for more information.

[1] Suares NC, Ford AC. Prevalence of, and risk factors for chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(9):1582-1591.

[2] Thomas R, Luthin D. Current and emerging treatments for irritable bowel syndrome with constipation and chronic idiopathic constipation: focus on prosecretory agents. Pharmacotherapy Pub. 2015; 613-630.

[3] Trulance™ [Prescribing Information]. Synergy Pharmaceuticals, Inc., New York City, New York: January 2017. http://content.stockpr.com/synergypharma/files/pages/synergypharma/db/147/description/PP-TRU-US-0175++Trulance+Prescribing+Information.pdf. Accessed July 25, 2017.

What is Trulance?

Trulance™ (plecanatide) 3 mg tablets is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). “Idiopathic” means the cause of the constipation is unknown. It is not known if Trulance is safe and effective in children less than 18 years of age.


  • Do not give Trulance to children who are less than 6 years of age. It may harm them.
  • You should not give Trulance to children 6 years to less than 18 years of age. It may harm them.
  • Do not take Trulance if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take Trulance, tell your doctor:

  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. It is not known if Trulance will harm your unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is not known if Trulance passes into your breast milk. Talk with your doctor about the best way to feed your baby if you take Trulance.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects

Diarrhea is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 4 weeks of Trulance treatment. Stop taking Trulance and call your doctor right away if you get severe diarrhea.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Trulance. For more information, ask your doctor or pharmacist.

You are encouraged to report side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088 or you can report side effects to Synergy Pharmaceuticals at 1-888-869-8869.

Please also see Medication Guide within the full Prescribing Information.

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This is a sponsored conversation written by me on behalf of Synergy Pharmaceuticals. The opinions and text are all mine.