Even on a good day, life has its challenges. Although work, family obligations, and carving out time for oneself can seem like a balancing act, these moments can also bring great joy. Now imagine if you had to conduct that balancing act while planning your day around access to a bathroom. Would you be able to attend your child’s school play? Remain focused at work? Enjoy a day at the beach? Unfortunately, those are the challenges many of the millions of people suffering from chronic idiopathic constipation (CIC) face each day.1

I recently learned a friend of mine has been suffering from CIC for many years. In college, we called her ‘The Cruise Director.’ She was always rallying groups of us to go off on big adventures and was making sure no one slept the day away. Now, years later, I couldn’t understand why my outgoing, vivacious, ‘doer’ friend had retreated into herself and more often than not would pass on invitations. I feel lucky that she finally let me know what was going on and the challenges she faces each day.

When Karen* first noticed she had a problem with constipation, she spent over a year trying to handle it herself. She tried copious amounts of fiber and lots of OTC laxatives before she finally told her doctor. She felt relieved when she was diagnosed and there was a name for her condition: chronic idiopathic constipation or CIC. CIC is a functional gastrointestinal (GI) disorder that is typically characterized by infrequent bowel movements (fewer than three a week) where there is no identifiable cause.1,2

Although she had a diagnosis, she continued to swing from the discomfort of constipation to the issues with diarrhea caused by the treatments she used. She remained fixated on knowing where accessible bathrooms were all day, every day. Even errands became a challenge. She continued to turn down both personal and professional opportunities — it was simply easier to stay at home as much as possible. Karen still didn’t feel okay bringing up her condition to friends. She wondered how she could work her digestive health into conversations and if she could, would anyone take her seriously?

woman looking through a window at home

Unfortunately, Karen’s situation is not unique. You are not alone if you feel like you’ve tried everything for your CIC but still haven’t found a treatment option that works for you. Click here to hear from people that truly understand what it’s like to have CIC and what they did to manage their constipation. If you feel that life seems to revolve around when and where you go to the bathroom, now may be the time to talk to your doctor about a prescription treatment option called Trulance™ (plecanatide). Trulance is indicated for adults with CIC and is designed to work like a natural peptide in your body which helps to provide the appropriate fluid levels in your intestines.3 Diarrhea is the most common side effect and can sometimes be severe.3 It is important to discuss the potential benefits and side effects with your doctor.3 See additional important safety information below.

When treating your constipation, you shouldn’t have to make compromises that ultimately keep you bound to a bathroom. If you are suffering from CIC, maybe it’s time to check in with your doctor to see if Trulance can help.

[1] Thomas R, Luthin D. Current and emerging treatments for irritable bowel syndrome with constipation and chronic idiopathic constipation: focus on prosecretory agents. Pharmacotherapy Pub. 2015; 613-630.

[2] Suares NC, Ford AC. Prevalence of, and risk factors for chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(9):1582-1591.

[3] Trulance™ [Prescribing Information]. Synergy Pharmaceuticals, Inc., New York City, New York: January 2017.  http://content.stockpr.com/synergypharma/files/pages/synergypharma/db/147/description/PP-TRU-US-0175++Trulance+Prescribing+Information.pdf. Accessed July 25, 2017.

What is Trulance?

Trulance™ (plecanatide) 3 mg tablets is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). “Idiopathic” means the cause of the constipation is unknown. It is not known if Trulance is safe and effective in children less than 18 years of age.


  • Do not give Trulance to children who are less than 6 years of age. It may harm them.
  • You should not give Trulance to children 6 years to less than 18 years of age. It may harm them.
  • Do not take Trulance if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take Trulance, tell your doctor:

  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. It is not known if Trulance will harm your unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is not known if Trulance passes into your breast milk. Talk with your doctor about the best way to feed your baby if you take Trulance.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects

Diarrhea is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 4 weeks of Trulance treatment. Stop taking Trulance and call your doctor right away if you get severe diarrhea.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Trulance. For more information, ask your doctor or pharmacist.

You are encouraged to report side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088 or you can report side effects to Synergy Pharmaceuticals at 1-888-869-8869.

Please also see Medication Guide within the full Prescribing Information.

*Name and identifying details changed to protect patient privacy.

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This is a sponsored conversation written by me on behalf of Synergy Pharmaceuticals. The opinions and text are all mine.