When we are feeling good, it’s rare to think about how our bodies keep us going so we can enjoy sunrises, walks on the beach, or time with family and friends. Just the other day I was joking with my son about how great it was that we didn’t have to think about keeping our hearts beating or consciously think about taking each breath. Unfortunately, folks with a chronic illness need to think a lot more about managing their health and how their bodieswoman resting on a bench drinking water function. Understanding their condition enables them to take steps to manage it. In our recent post on living with chronic idiopathic constipation (CIC), we learned about the challenges of living with this condition and also learned about a treatment option for adults with CIC. To better understand how this treatment option may work for adults with CIC, it is helpful to better understand how the digestive system works.

Without thinking about it, your body does a lot of work to keep you going each and every day. Your circulatory system keeps your blood moving.1 Your pulmonary system keeps you breathing.2 And your digestive system is a crucial part of keeping you going too. After you eat, your body breaks down your food as it passes through your intestines.3 Fluid produced by the body plays an important role the digestive process.Fluid helps to create stool consistency from the waste that’s left behind.3 Insufficient fluid can cause constipation and too much fluid may result in diarrhea.4 Uroguanylin (pronounced “yur-oh-gwah-nih-lin”) is a naturally occurring peptide that helps regulate the amount of fluid in the digestive tract.5,6 Uroguanylin responds to the changes that normally occur within your small intestine to produce the appropriate amount of fluid needed for well-formed bowel movements.5,6

Many people experience constipation at one time or another but for some people, long periods of constipation without a known cause could be CIC.7CIC is one of the most common functional gastrointestinal disorders worldwide, affecting approximately 33 million Americans.7,8

Many CIC sufferers swing from the discomfort associated with their constipation to the urgency and unpredictability of diarrhea. Trulance is a medication indicated for adults with CIC, designed to act like the natural uroguanylin in your body—helping to provide appropriate fluid levels in your intestines.9 Diarrhea is the most common side effect and can sometimes be severe.9 It is important to discuss the potential benefits and side effects with your doctor.9 Click here to learn more about how Trulance works. See additional important safety information below.

If you are suffering from CIC, it might be time to check in with your doctor to see if Trulance could help you find relief.

[1] Informed Health Online [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. How does the blood circulatory system work? 2010 Mar 12 [Updated 2016 Aug 1].

[2] Informed Health Online [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. How do lungs work? 2016 Nov 3 [Updated 2016 Nov 3]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK401240/

[3] National Institute of Diabetes and Digestive and Kidney Diseases. The digestive system & how it works. NIH Pub. 2013;13.

[4] Rose C, Parker A, Jefferson B, et al. The characterization of feces and urine: a review of the literature to inform advanced treatment technology. Crit Rev Environ Sci Technol. 2015;45(17):1827-1879.

[5] Hamra FK, Forte LR, Eber SL, et al. Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase. Proc Natl Acad Sci USA. 1993;90:10464–10468.

[6] Gonzalez-Martinez MA, Ortiz-Olvera NX, Mendez-Navarro J. Novel pharmacological therapies for management of chronic constipation. J Clin Gastroenterol. 2014;48(1):21–28.

[7] Suares NC, Ford AC. Prevalence of, and risk factors for chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(9):1582-1591.

[8] Thomas R, Luthin D. Current and emerging treatments for irritable bowel syndrome with constipation and chronic idiopathic constipation: focus on prosecretory agents. Pharmacotherapy Pub. 2015; 613-630.

[9] Trulance™ [Prescribing Information]. Synergy Pharmaceuticals, Inc., New York City, New York: January 2017. http://content.stockpr.com/synergypharma/files/pages/synergypharma/db/147/description/PP-TRU-US-0175++Trulance+Prescribing+Information.pdf. Accessed July 25, 2017.

What is Trulance?

Trulance™ (plecanatide) 3 mg tablets is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). “Idiopathic” means the cause of the constipation is unknown. It is not known if Trulance is safe and effective in children less than 18 years of age.


  • Do not give Trulance to children who are less than 6 years of age. It may harm them.
  • You should not give Trulance to children 6 years to less than 18 years of age. It may harm them.
  • Do not take Trulance if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take Trulance, tell your doctor:

  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. It is not known if Trulance will harm your unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is not known if Trulance passes into your breast milk. Talk with your doctor about the best way to feed your baby if you take Trulance.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects

Diarrhea is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 4 weeks of Trulance treatment. Stop taking Trulance and call your doctor right away if you get severe diarrhea.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Trulance. For more information, ask your doctor or pharmacist.

You are encouraged to report side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088 or you can report side effects to Synergy Pharmaceuticals at 1-888-869-8869.

Please also see Medication Guide within the full Prescribing Information.

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This is a sponsored conversation written by me on behalf of Synergy Pharmaceuticals. The opinions and text are all mine.